کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6024251 | 1188658 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Deep neural network with weight sparsity control and pre-training extracts hierarchical features and enhances classification performance: Evidence from whole-brain resting-state functional connectivity patterns of schizophrenia
ترجمه فارسی عنوان
شبکه عصبی عمیق با کنترل ریسک پذیری وزن و ویژگی های سلسله مراتبی عصاره های پیش از تمرین و افزایش عملکرد طبقه بندی: شواهد از مدل های همبستگی عملکردهای کل سیستم مغز و اعصاب اسکیزوفرنیا
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کلمات کلیدی
Group independent component analysisGICAMNISTDNNFNCMNIEPIDMNBOLDAALICADSMMSEICCAUC - AUCfunctional network connectivity - اتصال شبکه عملکردیFunctional connectivity - اتصال عملکردی Cross-validation - اعتبار سنجی متقابلblood-oxygenation-level-dependent - اکسیژن خون وابسته به سطح استautomated anatomical labeling - برچسب زدن آناتومیک اتوماتیکIndependent component analysis - تجزیه و تحلیل جزء مستقلanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceEcho-planar imaging - تصویربرداری اکو فلاریdiffeomorphic anatomical registration through exponentiated Lie algebra - ثبت نام آناتومی دیفیزمورفیک از طریق جبر انعطاف پذیرindependent component - جزء مستقلDARTEL - جست و خیزLeast absolute shrinkage and selection operator - حداقل اپراتور انقباض و انتخاب مطلقmean squared error - خطای میانگین مربعاتDiagnostic and Statistical Manual of Mental Disorders - راهنمای تشخیصی و آماری اختلالهای روانیAutoencoder - رمزگشای خودروDefault-mode network - شبکه حالت پیش فرضDeep neural network - شبکه عصبی عمیقCorrelation coefficient - ضریب همبستگیIntra-class correlation coefficient - ضریب همبستگی درونی کلاسGray matter - ماده خاکستریCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیarea under the receiver operating characteristic curve - محدوده تحت منحنی مشخصه عملکرد گیرندهMontreal Neurological Institute - موسسه عصبی مونترالLASSO - کمندhealthy control - کنترل سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Functional connectivity (FC) patterns obtained from resting-state functional magnetic resonance imaging data are commonly employed to study neuropsychiatric conditions by using pattern classifiers such as the support vector machine (SVM). Meanwhile, a deep neural network (DNN) with multiple hidden layers has shown its ability to systematically extract lower-to-higher level information of image and speech data from lower-to-higher hidden layers, markedly enhancing classification accuracy. The objective of this study was to adopt the DNN for whole-brain resting-state FC pattern classification of schizophrenia (SZ) patients vs. healthy controls (HCs) and identification of aberrant FC patterns associated with SZ. We hypothesized that the lower-to-higher level features learned via the DNN would significantly enhance the classification accuracy, and proposed an adaptive learning algorithm to explicitly control the weight sparsity in each hidden layer via L1-norm regularization. Furthermore, the weights were initialized via stacked autoencoder based pre-training to further improve the classification performance. Classification accuracy was systematically evaluated as a function of (1) the number of hidden layers/nodes, (2) the use of L1-norm regularization, (3) the use of the pre-training, (4) the use of framewise displacement (FD) removal, and (5) the use of anatomical/functional parcellation. Using FC patterns from anatomically parcellated regions without FD removal, an error rate of 14.2% was achieved by employing three hidden layers and 50 hidden nodes with both L1-norm regularization and pre-training, which was substantially lower than the error rate from the SVM (22.3%). Moreover, the trained DNN weights (i.e., the learned features) were found to represent the hierarchical organization of aberrant FC patterns in SZ compared with HC. Specifically, pairs of nodes extracted from the lower hidden layer represented sparse FC patterns implicated in SZ, which was quantified by using kurtosis/modularity measures and features from the higher hidden layer showed holistic/global FC patterns differentiating SZ from HC. Our proposed schemes and reported findings attained by using the DNN classifier and whole-brain FC data suggest that such approaches show improved ability to learn hidden patterns in brain imaging data, which may be useful for developing diagnostic tools for SZ and other neuropsychiatric disorders and identifying associated aberrant FC patterns.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 124, Part A, 1 January 2016, Pages 127-146
Journal: NeuroImage - Volume 124, Part A, 1 January 2016, Pages 127-146
نویسندگان
Junghoe Kim, Vince D. Calhoun, Eunsoo Shim, Jong-Hwan Lee,