Differential effects of the APOE genotype on brain function across the lifespan

►APOE genotype has different consequences for brain function depending on age. ►Differential aging processes in ε4-carriers may underlie increased risk of old-age pathology. ►Functional imaging techniques are sensitive to the effects of APOE on brain physiology. ►Our results may explain inconsistencies in the literature on APOE and brain function.