Mucin layers and multilayers — Physicochemical properties and applications

The present review summarizes recent, and important previous, findings on properties of mucin layers and multilayers and ways to tailor their properties. Specifically, progress has been made in understanding the effects of mucin type, preparations, ambient conditions and surface properties on adsorption and on mixed layer assembly including multilayers. Apart from structural features the stability, lubrication and biological functions of such layers are addressed.

Graphical AbstractProposed film architecture of an adsorbed mucin layer, a mixed layer and a multilayer film.Figure optionsDownload high-quality image (46 K)Download as PowerPoint slideResearch Highlights
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• Type, purity and molecular weight of mucins affect layer formation and surface interactions
• Mixed layers can be formed by mucin and serum proteins or enzymes
• Mucin multilayers can be assembled with chitosan and lactoperoxidase
• Mucin layers are lubricating and can reduce bacterial colonization and immunological response
• Mucins may have potential as biomaterial coating, salivary substitutes and in vitro mucous models