کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6044052 | 1581468 | 2016 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Original ArticleGamma Knife Radiosurgery for Atypical and Anaplastic Meningiomas Original ArticleGamma Knife Radiosurgery for Atypical and Anaplastic Meningiomas](/preview/png/6044052.png)
BackgroundAtypical and anaplastic meningiomas have much higher recurrence rates after surgical resection compared with benign meningiomas, but the role of adjuvant radiosurgery remains unclear. This study was undertaken to evaluate the outcomes of gamma knife radiosurgery for patients with atypical and anaplastic meningiomas.MethodsIn this retrospective analysis of a prospectively maintained database, 46 patients with histologically proven atypical or anaplastic meningiomas by current World Health Organization (WHO) criteria underwent postoperative Gamma Knife radiosurgery between 1993 and 2013. The median follow-up period was 32.6 months. The median tumor volume and margin dose were 11.7 mL (range, 2-53 mL) and 13.1 Gy (range, 12.0-16.5 Gy), respectively.ResultsLocal control at 3 and 5 years was 50.6% and 32.1%, respectively. Gender (PÂ = 0.013) and marginal dose less than or equal to 13Gy (PÂ = 0.049) were associated with the local control. The 3- and 5-year overall survival for patients with WHO grade II was 97.1% and 88.3%, respectively, compared with 66.7% and 66.7% for patients with WHO grade III meningiomas. Radiation therapy before Gamma Knife radiosurgery (GKRS; PÂ = 0.018) and tumor grade (PÂ = 0.019) were the factors associated with a worse overall survival rate. Fourteen patients (30.4%) developed adverse radiation effects after GKRS treatment, and all were Radiation Therapy Oncology Group grade I.ConclusionsPostoperative GKRS treatment for patients with atypical and anaplastic meningioma is challenging. More aggressive treatment, including of safely maximizing the extent of surgical resection and using a higher margin dose (>13Gy), should be applied to achieve better local control.
Journal: World Neurosurgery - Volume 87, March 2016, Pages 557-564