کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6051653 1583324 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum cytokine profile among Brazilian children of African descent with periodontal inflammation and sickle cell anaemia
ترجمه فارسی عنوان
مشخصات سیتوکین سرم در میان کودکان برزیل تبار آفریقایی با التهاب پریودنتال و آنمی سلولی داسی شکل
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

ObjectiveThe aim of this study was to evaluate possible immunologic relationships between sickle cell anaemia (SCA) and periodontal inflammation and its impact on serum cytokines.DesignTwenty-five Brazilian children of African descent were involved in this study and divided in two groups: SCA (n = 10): confirmed diagnosis of homozygous anaemia; and CTR-control (n = 15): no sickle anaemia. Clinical examination included comprehensive medical (routine physical evaluation) and periodontal exams: plaque index (PI), bleeding on probing (BoP), and haematological analysis. Serum samples were collected for cytokine evaluation by microarray. Clinical and laboratorial parameters were compared statistically (alpha = 5%).ResultsThe higher values of PI and BoP were similar for both groups (p > 0.05) confirming a diagnosis of generalized gingivitis for all individuals. Intergroup analysis showed higher levels of interferon gamma (IFNγ), tumour necrosis alpha (TNFα), interleukin (IL)-4, -5, -8, -10 and 13 only in the SCA group (p < 0.05). In addition, PI was negatively correlated with IL-2, IL-4, IL-5, IL-6, IL-8 and IL-13, while BoP was positively correlated with IL-10.ConclusionWithin the limits of the present study, it was concluded that SCA increase the levels of serum cytokines regardless of the presence of periodontal inflammation. Therefore, a direct immunological relationship between SCA and periodontal inflammation was not established.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 58, Issue 5, May 2013, Pages 505-510
نویسندگان
, , , , ,