Isoproterenol modulates matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor-2 (TIMP-2) in rat parotid gland

Our results suggest the presence of a isoproterenol-dependent modulation of extracellular matrix components. Such a modulation seems to be associated with β-adrenergic agonist-induced hyperplasy, occurring during the first 24 h of agonist treatment, and hypertrophy of the parotid gland.