The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients

RAGE is strongly expressed in the gingiva of diabetic patients with periodontitis and with severe periodontitis alone, the latter indicating RAGE activation even in the absence of hyperglycemia. However our findings are based on relatively small sample size. With a larger patient population, some of our other findings may have reached statistical significance.