کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6055201 1198793 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of −308 TNF-α promoter polymorphism with clinical aggressiveness in patients with head and neck squamous cell carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Association of −308 TNF-α promoter polymorphism with clinical aggressiveness in patients with head and neck squamous cell carcinoma
چکیده انگلیسی

SummaryGenetic polymorphisms in the promoter region of the tumour necrosis factor-α (TNF-α) gene are involved in the regulation of the expression levels of its cytokine. Besides, these polymorphisms have been associated with the clinical behaviour of cancer. We investigated the −308 promoter region polymorphisms of the TNF-α gene and its association with the clinicopathological factors of a head and neck squamous cell carcinoma (HNSCC) sample. Furthermore, we analysed the impact of all the variables on the overall survival of patients. A sample of HNSCC (n = 89) was evaluated. Clinicopathological factors and overall survival data were gathered. The TNF-α gene was analysed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data analyses were performed by using bivariate and multivariate statistical tests. Significance was set at p < 0.05. HNSCC subjects carrying the A allele (GA/AA) exhibited associations with poor performance status (OR = 2.82, p = 0.039), lesions located on posterior areas (OR = 4.02, p = 0.002), and large-size tumours (OR = 2.91, p = 0.015). Subjects carrying only AA genotype exhibited association with poor performance status (OR = 6.667, p = 0.007). A worse overall survival was noted in subjects with large tumours (OR = 4.87, p = 0.005) and locoregional metastatic disease (OR = 2.50, p = 0.018). Our data suggests that the presence of the A allele/AA haplotype in HNSCC individuals might contribute to the higher clinical aggressiveness of malignant disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 47, Issue 9, September 2011, Pages 888-894
نویسندگان
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