کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6087034 | 1589422 | 2016 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults](/preview/png/6087034.png)
- Plant-derived virus-like particle quadrivalent influenza vaccine is safe and well-tolerated
- One dose of vaccine elicits a strong, sustained and cross-reactive immune response
- One dose of vaccine satisfy all CHMP surrogate correlates of protection in adults
- The plant-derived vaccine induces HA-specific and cross-reactive memory CD4 T cells
Recent issues regarding efficacy of influenza vaccines have re-emphasized the need of new approaches to face this major public health issue. In a phase 1-2 clinical trial, healthy adults received one intramuscular dose of a seasonal influenza plant-based quadrivalent virus-like particle (QVLP) vaccine or placebo. The hemagglutination inhibition (HI) titers met all the European licensure criteria for the type A influenza strains at the 3 μg/strain dose and for all four strains at the higher dosages 21 days after immunization. High HI titers were maintained for most of the strains 6 months after vaccination. QVLP vaccine induced a substantial and sustained increase of hemagglutinin-specific polyfunctional CD4 T cells, mainly transitional memory and TEMRA effector IFN-γ+ CD4 T cells. A T cells cross-reactive response was also observed against A/Hong-Kong/1/1968 H3N2 and B/Massachusetts/2/2012. Plant-based QVLP offers an attractive alternative manufacturing method for producing effective and HA-strain matching seasonal influenza vaccines.
Journal: Clinical Immunology - Volume 168, July 2016, Pages 72-87