کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087223 | 1589428 | 2015 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis](/preview/png/6087223.png)
- Two subsets of s-JIA can be identified on the basis of serum IL-6/IL-18 levels.
- IL-6-dominant subset was more likely to have more severe joint disease.
- IL-18-dominant subset was more likely to develop MAS.
- Serum IL-18 levels might be useful to predict MAS development.
- The cutoff value of serum IL-18 levels to predict MAS development is 47750Â pg/ml.
To assess the role of IL-6/IL-18 in the pathogenesis of systemic juvenile idiopathic arthritis (s-JIA) and to investigate the clinical significance of serum IL-18 levels for predicting macrophage activation syndrome (MAS) development, we measured the serum IL-6/IL-18 levels in 76Â s-JIA patients, including 15 with MAS, and compared them with the clinical features. We identified 2 distinct subsets on the basis of serum IL-6/IL-18 levels. The IL-18-dominant subset had more patients who developed MAS. Serum IL-18 levels during active phase in patients with MAS were significantly higher than those without MAS. The cutoff value of serum IL-18 levels for predicting MAS development was 47750Â pg/ml. The patients with IL-18 dominant subset at their disease onset were significantly more likely to develop MAS after TCZ therapy started. IL-18 might have a key role in the pathogenesis of MAS. Serum IL-18 levels >Â 47750Â pg/ml might be useful to predict MAS development.
Journal: Clinical Immunology - Volume 160, Issue 2, October 2015, Pages 277-281