کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087364 1207358 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness
چکیده انگلیسی


- ILC2s are selectively elevated in the eosinophilic nasal polyp endotype.
- Systemic corticosteroid treatment was associated with reduced polyp ILC2s.
- Corticosteroids induce mouse lung ILC2 apoptosis in vivo and in vitro.

Group 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps, but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid use is unknown. Here, we show that eosinophilic nasal polyps contained double the number of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were also reduced by 50% in patients treated with systemic corticosteroids. Further, using a fungal allergen challenge mouse model, we detected greatly reduced Th2 cytokine-producing and Ki-67 + proliferating lung ILC2s in mice receiving dexamethasone. Finally, ILC2 Annexin V staining revealed extensive apoptosis after corticosteroid treatment in vivo and in vitro. Thus, ILC2s are elevated in the eosinophilic nasal polyp endotype and systemic corticosteroid treatment correlated with reduced polyp ILC2s. Finally, allergen-challenged mice showed reduced ILC2s and increased ILC2 apoptosis after corticosteroid treatment suggesting that ILC2 may be responsive to corticosteroids in eosinophilic respiratory disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 155, Issue 1, November 2014, Pages 126-135
نویسندگان
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