کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087450 | 1207365 | 2014 | 7 صفحه PDF | دانلود رایگان |
- Natural IgM-antibodies to PC may have protective properties in SLE.
- Lower levels of IgM anti-PC were associated with carotid plaque in SLE.
- Combining IgM anti-PC, adiponectin, and sE-selectin was better at predicting plaque.
- IgM anti-PC may be a valuable biomarker for subclinical atherosclerosis in lupus.
Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p = 0.004 and p = 0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone.These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgM anti-PC levels as a biomarker for subclinical CV disease.
Journal: Clinical Immunology - Volume 153, Issue 1, July 2014, Pages 1-7