کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087601 | 1207374 | 2013 | 12 صفحه PDF | دانلود رایگان |
- TSPAN33 is a biomarker for activated B cells.
- TSPAN33 is expressed in certain Lymphomas.
- TSPAN33 is expressed in some autoimmune diseases (SLE and RA).
- TSPAN33 is a potential diagnostic and therapeutic target of malignant B cells.
We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
Journal: Clinical Immunology - Volume 149, Issue 3, Part B, December 2013, Pages 388-399