کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087740 1207397 2012 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
REVIEWImmunodominance: A pivotal principle in host response to viral infections
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
REVIEWImmunodominance: A pivotal principle in host response to viral infections
چکیده انگلیسی

We encounter pathogens on a daily basis and our immune system has evolved to mount an immune response following an infection. An interesting phenomenon that has evolved in response to clearing bacterial and viral infections is called immunodominance. Immunodominance refers to the phenomenon that, despite co-expression of multiple major histocompatibility complex class I alleles by host cells and the potential generation of hundreds of distinct antigenic peptides for recognition following an infection, a large portion of the anti-viral cytotoxic T lymphocyte population targets only some peptide/MHC class I complexes. Here we review the main factors contributing to immunodominance in relation to influenza A and HIV infection. Of special interest are the factors contributing to immunodominance in humans and rodents following influenza A infection. By critically reviewing these findings, we hope to improve understanding of the challenges facing the discovery of new factors enabling better anti-viral vaccine strategies in the future.

► Immunodominance (ImDc) plays an important role following viral infections. ► HIV-1 and influenza infections lead to immunodominant responses in animals. ► Immunodominant peptides are preferentially recognized by host's immune system. ► Antigen processing/presentation steps contribute to ImDc following an infection. ► Viral mutation, CD8 T cell precursor number and memory T cells contribute to ImDc.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 143, Issue 2, May 2012, Pages 99-115
نویسندگان
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