کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087812 | 1207408 | 2011 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immune system development during early childhood in tropical Latin America: Evidence for the age-dependent down regulation of the innate immune response Immune system development during early childhood in tropical Latin America: Evidence for the age-dependent down regulation of the innate immune response](/preview/png/6087812.png)
The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5Â years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6-9Â months, 22-26Â months, and 48-60Â months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4+ and CD8+ T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3+ T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.
Journal: Clinical Immunology - Volume 138, Issue 3, March 2011, Pages 299-310