کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6113657 | 1212349 | 2014 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis-A critical review
ترجمه فارسی عنوان
مطالعات اپیدمیولوژیک و غیر بالینی در بررسی اثرات آهن در سرطان پستان - یک بررسی انتقادی
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کلمات کلیدی
کمبود آهن، کم خونی سرطان زایی، پیشرفت تومور، غیر کلاسیک، آهن داخل وریدی آهن تزریقی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
چکیده انگلیسی
The efficacy and tolerability of intravenous (i.v.) iron in managing cancer-related anemia and iron deficiency has been clinically evaluated and reviewed recently. However, long-term data in cancer patients are not available; yet, long-term i.v. iron treatment in hemodialysis patients is not associated with increased cancer risk. This review summarizes epidemiological and nonclinical data on the role of iron in carcinogenesis. In humans, epidemiological data suggest correlations between certain cancers and increased iron exposure or iron overload. Nonclinical models that investigated whether iron can enhance carcinogenesis provide only limited evidence relevant for cancer patients since they were typically based on high iron doses as well as injection routes and iron formulations which are not used in the clinical setting. Nevertheless, in the absence of long-term outcome data from prospectively defined trials in i.v. iron-treated cancer patients, iron supplementation should be limited to periods of concomitant anti-tumor treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 89, Issue 1, January 2014, Pages 1-15
Journal: Critical Reviews in Oncology/Hematology - Volume 89, Issue 1, January 2014, Pages 1-15
نویسندگان
Yves Beguin, Matti Aapro, Heinz Ludwig, Lee Mizzen, Anders Ãsterborg,