کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6113709 1212361 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overview of biomarkers in metastatic colorectal cancer: Tumour, blood and patient-related factors
ترجمه فارسی عنوان
بررسی عوامل زیستی در سرطان متاستاتیک کولورکتال: تومور، خون و عوامل مربوط به بیمار
کلمات کلیدی
سرطان روده بزرگ، بیومارکرها، عوامل تومور، عوامل بیمار، پیش بینی کننده پیش آگهی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
During the last 20 years there have been major therapeutic developments in colorectal cancer (CRC) with the introduction of multiple novel therapeutic agents into routine clinical practice. This has improved survival in both the adjuvant and advanced disease settings. However, improvements have come with substantial increases in expense to the community and potential toxicity to the patient. There has been substantial research to identify tumour factors in CRC that predict treatment response and survival outcomes. This research has identified clinically useful predictive biomarkers to aid clinical decision making, such as the presence or absence of KRAS gene mutations which can determine the benefit of using epidermal growth factor receptor (EGFR) inhibiting antibodies. However, less attention has been paid to the identification and impact of predictive patient-derived factors such as age, gender and the presence of comorbid conditions or evidence of a systemic inflammatory response. In this article, the current concepts of tumour and patient-related predictive factors in CRC management are reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 85, Issue 2, February 2013, Pages 121-135
نویسندگان
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