کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6113964 | 1213513 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Platelet microparticles in cryopreserved platelets: Potential mediators of haemostasis
ترجمه فارسی عنوان
پراکندگی پلاکتی در پلاکت های غربال گرایی: واسطه های بالقوه هموستاز
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کلمات کلیدی
فریزر پلاکت، میکرو ذرات،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
چکیده انگلیسی
Platelet concentrates can be cryopreserved in dimethylsulphoxide (DMSO) and stored at â80â°C, which increases the shelf-life from 5 days to up to 4 years. Cryopreserved platelets have been shown to contain a high number of microparticles that have in vitro haemostatic activity. Further, when transfused, cryopreserved platelets have been shown to be at least as haemostatically active, as liquid-stored platelets, if not more so. Given that microparticles are traditionally considered to be pro-coagulant, it is likely that their presence in the cryopreserved component contributes to this haemostatic effect. However, as microparticles are known to mediate many physiological and pathological processes, including in thrombosis and cancer development and progression, further work is warranted to fully understand the functional scope of the microparticles in cryopreserved platelets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 53, Issue 2, October 2015, Pages 146-152
Journal: Transfusion and Apheresis Science - Volume 53, Issue 2, October 2015, Pages 146-152
نویسندگان
Lacey Johnson, Sarah Raynel, Jerard Seghatchian, Denese C. Marks,