کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6114583 1214226 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormonal modulation of the immune system - A spotlight on the role of progestogens
ترجمه فارسی عنوان
مدولاسیون هورمونی سیستم ایمنی بدن - توجه ویژه به نقش پروژسترون ها
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
The interplay between the sex hormones such as progestogens and the immune system is very complex. Multiple factors affect immunomodulatory effects of the progestogens including fluctuations in the endogenous sex hormone levels, stress, use of exogenous hormones (dose, route and the timing of administration), and alterations in the hormonal metabolism. Although immunomodulatory effects of progesterone, especially progesterone's effect on T cells, T cell subsets and their ratios, dose effects, and the use of synthetic progestins have been studied, there are still wide open areas for further explorations of the progestogens' multifaceted impact on the immune system. Better understanding of the intricate immunomodulatory effects of the progestins may pave the path to developing clinically meaningful therapeutic interventions in certain autoimmune diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 14, Issue 6, June 2015, Pages 536-542
نویسندگان
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