Invariant NKT cells provide innate and adaptive help for B cells

- iNKT cells provide innate, cognate help for T-dependent type II antigens.
- iNKT cells provide adaptive, noncognate help for T-D type 1 and T-I antigens.
- Cognate antigen drives splenic iNKT cells to arrest in the MZ then help GC B cells.
- Nanoparticles containing glycolipids are highly efficient activators of iNKT cells.
- Glycolipid and antigen containing nanoparticles are promising vaccine candidates.