Immunity to fungi

► Genetic defects predispose to fungal infections and illustrate key defense mechanisms. ► C-type lectin receptor signaling pathways play a central role in immunity to fungi. ► Toll-like receptor agonism can resolve fungal infections. ► IL-17 is a key mediator of antifungal immunity, particularly at mucosal surfaces. ► Experimental fungal vaccines elicit protective immunity by Th1 and Th17 cells.