Developmental programming of natural killer and innate lymphoid cells

► ILCs include NK cells, nuocytes/NH cells, LTi cells and NKp46+ IL-22+ cells. ► ILC rapidly produce cytokines (IL-5, -13, -17A, -22, IFN-g) required for immunity to infection. ► Transcription factors program ILC differentiation from lymphoid precursors. ► ILC and Th responses are coordinated during innate and adaptive immunity.