Development and function of group 2 innate lymphoid cells

► ILC2 provide an innate source of type-2 cytokines (IL-5, IL-9 and IL-13). ► IL-13 production by ILC2 is critical to anti-helminthic immunity. ► ILC2 regulate allergic airways inflammation and lung tissue homeostasis. ► ILC2 development is instructed by the transcriptional regulators, RORα and Gata3. ► Bone marrow ILC2 precursors give rise to mature ILC2 upon adoptive transfer.