Lymphotoxin network pathways shape the tumor microenvironment

► Lymphotoxin and LIGHT mediate inflammation in a range of human autoimmune diseases. ► The Lymphotoxin-LIGHT Network mediates cancer inflammation in hematologic and solid tumors. ► Frequent somatic mutations implicate HVEM as a universal tumor suppressor gene in lymphoma. ► Rewiring Lymphotoxin LIGHT Network can alter tissue microenvironments to promote tumor immunity.