Integration of retroviral vectors

► Integration site analysis: unbiased methods to detect retroviral integrations. ► Retroviral integrase: structural insights into the mechanism of retroviral integration. ► Preferential integration: virus and host factors determining target site selection. ► Insertional mutagenesis: oncogenicity and risk for posttranscriptional toxicity. ► Integrase-defective lentiviral vectors: applications in gene therapy.