The role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies

► Induced pluripotent stem cells (iPSCs) may provide a renewable stem cell source for use in research. ► Patient-derived iPSCs are a valuable platform for primary immunodeficiency disease modeling and correction. ► Robust in vitro hematopoietic differentiation protocols are key to study the molecular mechanisms underlying immune manifestations of PID. ► Human T lineage development can be modeled using the iPSC/OP-9DL system. ► Safety measures need to be in place before translating iPSC technology into the clinical arena.