کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116750 | 1216386 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Considerations on regulatory sequences of the distal promoter region of the HLA-G gene
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کلمات کلیدی
URRHSF-1HSEISRELCRinfCIITA - CIThuman leucocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیExpectation maximization algorithm - الگوریتم به حداکثر رساندن انتظارinterferon - اینترفرونheat shock factor 1 - عامل شوک گرما 1heat shock element - عنصر شوک گرماmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیUTR یا untranslated regions - منطقه ترجمه نشدهuntranslated region - منطقه غیر ترجمهlocus control region - منطقه کنترل منطقهSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدGas - گاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Considerations on regulatory sequences of the distal promoter region of the HLA-G gene Considerations on regulatory sequences of the distal promoter region of the HLA-G gene](/preview/png/6116750.png)
چکیده انگلیسی
HLA-G codes for an immunoregulatory protein with tissue-specific expression, its unique promoter regulatory region is responsible for this feature. The aim of the present study was to explore motif composition as well as identify haplotypes in the HLA-G 5â² distal promoter region. The sample was composed by 176 euro-descendents individuals genotyped by Sequence Based Typing of HLA-G distal promoter, encompassing 16 SNPs. Haplotypes were inferred by the expectation maximization algorithm. Only haplotypes with frequency higher than 1% were aligned to check for similarities and differences and thirteen haplotypes remained. For a better understanding of the nucleotide diversity of the analyzed region our approach was to split the whole sequence into two regions. Two contrasting haplotype groups were found in both regions, allowing us to suggest the existence of different transcription factors capable of binding cis elements while the intra-group variations suggest the intensity modulation of binding with regulatory factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 74, Issue 4, April 2013, Pages 473-477
Journal: Human Immunology - Volume 74, Issue 4, April 2013, Pages 473-477
نویسندگان
José Samuel da Silva, Renata Slowik, Maria da Graça Bicalho,