کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6116943 1591548 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The variegated aspects of Immunoglobulin A
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The variegated aspects of Immunoglobulin A
چکیده انگلیسی
Although immunoglobulins (Ig) of the A isotype were discovered more than 50 years ago, their homeostatic function, production and specificity has only lately started to be unravelled. We have recently described that the level of IgAs is genetically determined and contributes to microbiota diversification via establishing a positive feedback loop of IgA production. Here we show that the amount of both fecal and serum IgAs is intermediate in a F1 BALB/c x C57BL/6 mixed background. Naïve mice that have never been exposed to certain bacterial strains but that carry innate IgAs that react towards those bacteria undergo de novo differentiation of antigen-specific responses, indicating that there is not just a recall of a pre-existing innate IgA response. We also demonstrate that, differently from pathogenic bacteria, a commensal does not induce systemic IgG response but only a mucosal IgA response. Thus IgAs come into different flavours and can potentiate their own production, but also drive the development of new specificities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 178, October 2016, Pages 45-49
نویسندگان
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