کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117160 | 1217168 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thymic precursors of TCRαβ+CD8αα+ intraepithelial lymphocytes are negative for CD103
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
CD5+TCRαβ+ cells in CD4âCD8â double negative (DN) thymocytes are generally regarded as the thymic precursors of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes (IELs). However, this population is not homogenous and can be subdivided based on the expression of cell surface markers such as CD103. In this study, we aimed to define a cell population that is enriched in thymic IEL precursors. Here we report that only CD103â but not CD103+cells in the CD5+TCRαβ+ DN thymocyte population can give rise to TCRαβ+CD8αα+ IELs or IEL-like cells in in vivo injections and in vitro cultures, respectively. In addition, we demonstrate that IL-15 stimulation alone is sufficient for upregulation of CD8αα in CD103âCD5+TCRαβ+ DN thymocytes. We also found that the CD103âCD5+TCRαβ+ DN population can be further separated into two fractions: CD69â/lo and CD69+. Of these two fractions, only CD69â/lo cells can give rise to CD8αα IEL-like cells in the presence of IL-15 in in vitro cultures. Based on these results, we conclude that a CD69â/loCD103âCD5+TCRαβ+ DN population is highly enriched in thymic IEL precursors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 163, Issue 1, January 2015, Pages 40-48
Journal: Immunology Letters - Volume 163, Issue 1, January 2015, Pages 40-48
نویسندگان
Xianghua Guo, Yuriko Tanaka, Motonari Kondo,