Effective induction of anti-tumor immunity using p5 HER-2/neu derived peptide encapsulated in fusogenic DOTAP cationic liposomes co-administrated with CpG-ODN

- p5 was efficiently loaded into DOTAP-DOPE-cholesterol + CpG liposomes by urea method.
- This preparation effectively induced CD8+ producing IFN-γ cells and CTL response.
- Our cationic liposomes efficiently impacted on mice model of breast tumor growth.
- Both CpG and DOPE was found necessary for an optimum anti-tumor immunity effect.