کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117202 | 1217170 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clonal differences in IgE antibodies affect cutaneous anaphylaxis-associated thermal sensitivity in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Cellular and molecular mediators of immune responses are increasingly implicated in acute and chronic pain pathophysiologies. Here we demonstrate that passive cutaneous IgE/Ag anaphylaxis provokes increased thermal sensitivity in the hind paw tissue of mice. The murine anti-DNP IgE antibodies SPE-7 and É26 are known to induce differential cytokine production in bone marrow cultured mast cells in vitro without antigen challenge. We found a novel, antigen-dependent heterogeneity in the thermal pain responses elicited in the hind paws between SPE-7 and É26 sensitized DNP-challenged mice. Mice experienced pronounced hind paw thermal sensitivity lasting 6Â h after DNP challenge when sensitized with SPE-7 but not É26 IgE. The two IgE clones induced equivalent hind paw edema, neutrophil influx, cytokine production, and reduction in tissue histamine content in vivo, and bound to the same or overlapping epitopes on the DNP antigen in vitro. Therefore IgE antibodies against the same antigen can induce comparable inflammation, yet contribute to markedly different anaphylaxis-associated pain within an allergic response, suggesting that non-canonical IgE binding partners such as sensory neurons may play a role in allergy-related pain responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 162, Issue 1, Part A, November 2014, Pages 149-158
Journal: Immunology Letters - Volume 162, Issue 1, Part A, November 2014, Pages 149-158
نویسندگان
Madison Mack, Elena Tonc, Alyssa Ashbaugh, Abigail Wetzel, Akilah Sykes, Camilla Engblom, Estela Shabani, Carolina Mora-Solano, Anna Trier, Linnea Swanson, Emily Ewan, Tijana Martinov, Devavani Chatterjea,