کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117304 | 1217182 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The plasma levels of the cytokines in opium-addicts and the effects of opium on the cytokines secretion by their lymphocytes
ترجمه فارسی عنوان
سطح پلاسمایی سیتوکین ها در معتادان تریاک و اثرات تریاک بر ترشح سیتوکین ها توسط لنفوسیت های آنها
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The aim of this study was to evaluate the effects of opium addiction on the secretion of IL-4, IFN-γ, IL-6 and TGF-β under in vivo and in vitro conditions. The blood samples were collected and PBMCs were cultured in RPMI1640 with and without opium for 48 h. The levels of the cytokines were measured using ELISA technique. The results showed that plasma levels of IL-4 and IFN-γ were significantly lower and IL-6 and TGF-β were higher in plasma taken from opium-addicted subjects. The concentrations of all the cytokines in opium-addicted subjects in in vitro condition were significantly lower than the control group. Addicted subjects cultured lymphocytes significantly decrease secreted IL-4, IL-6 and TGF-β but not IFN-γ in response to being cultured with opium, where as IFN-γ was increased in controls. These results may explain the frequent microbial infections and an increased tumor incidence seen in addicted patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 152, Issue 1, April 2013, Pages 42-46
Journal: Immunology Letters - Volume 152, Issue 1, April 2013, Pages 42-46
نویسندگان
Saeedeh Nabati, Gholamreza Asadikaram, Mohammad Kazemi Arababadi, Gholamabbas Shahabinejad, Mohsen Rezaeian, Mehdi Mahmoodi, Derek Kennedy,