Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells

► We examined development of TCRαβ CD8αα IELs in RhoH knockout (KO) mice. ► RhoH KO mice had normal number of TCRαβ CD8αα T cells in the intestine. ► Activation of TCRαβ CD8αα IELs was impaired in RhoH KO mice. ► We propose a distinct molecular requirement for RhoH among agonist selected T cells.