Protective role of synthetic oligodeoxynucleotides expressing immunosuppressive TTAGGG motifs in concanavalin A-induced hepatitis

► Suppressive ODNs significantly reduce liver necroinflammatory injury and serum IFN-γ level in Con A-induced hepatitis model. ► The mortality of suppressive ODNs-treated mice is reduced post Con A challenge. ► Suppressive ODNs inhibit the development of Con A-induced hepatitis through down-regulation of STAT1/4 and T-bet pathways. ► Suppressive ODNs may be of use in the treatment of autoimmune or viral hepatitis in humans.