Cross-talk between the complement and the kinin system in vascular permeability

► Complement and kinin systems play a role in hereditary and acquired angioedema. ► C1-inhibitor controls activation of both kinin and complement systems. ► Bradykinin contributes to angioedema attacks interacting with B2 receptors. ► Interaction of high molecular weight kininogen with gC1qR induces bradykinin release. ► B1 and gC1q receptors represent novel therapeutic targets for angioedema attacks.