Calcineurin subunit B is an immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection

- We used human PBMC-derived and mice marrow-derived dendritic cells as models.
- We demonstrated that recombinant human calcineurin subunit B (CnB) induced phenotypic maturation of human PBMC-DCs and increased the secretion of cytokines.
- In vivo experiments, we used murine models to examine the adjuvant effect of CnB on recombinant pneumolysin antigen (PN) specific immune responses.
- It effectively promoted mixed Th1/Th2 type immune response.