CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan

► Human eosinophils internalize M. bovis BCG under non-opsonic conditions. ► We find that ManLAM down-regulates EPO and TNFα release by eosinophils. ► ManLAM is recognized by CR3 on eosinophils through a PI3K-dependent pathway. ► ManLAM inhibits TLR2-mediated eosinophil.