Novel roles for TIM-1 in immunity and infection

► The TIM-1 pathway is associated with susceptibility to asthma. ► Recent data suggest novel roles on T cells, B cells, iNKT cells and epithelial cells. ► TIM-1 ligands have been identified, including LMIR5, phosphatidylserine, and viruses. ► Models are proposed to account for the diverse activities of the TIM-1 pathway.