IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells

► We examine the culture conditions to induce differentiation of NCR22 cells in vitro. ► NCR22 phenotypes are CD3−CD127+NKp46+NK1.1low/neg. ► NCR22 cells are differentiated from CD127+CD117+ precursors.