Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation

► Clonotypic CD4+ T cells in Peyer's patches from TCR transgenic mice consist of naïve and memory phenotypic cells. ► Peyer's patch CD4+ T cells with naïve phenotypes produced higher IL-6 than splenic CD4+ T cells with the phenotypes. ► Peyer's patch naïve CD4+ T cells express higher Gabpb1 than those of spleen.