Experimental intracerebral vaccination protects mouse from a neurotropic virus by attracting antibody secreting cells to the CNS

► We investigated the immune response in intracerebrally vaccinated mouse. ► Serum antibodies were highly produced in intracerebrally vaccinated mice. ► Antibody secreting cells were infiltrated within intracerebral region. ► Chemoattractant proteins were expressed in intracerebrally vaccinated mice brain. ► Intracerebrally vaccinated mice survived after intracerebral virus challenge.