Liprin-α is involved in exocytosis and cell spreading in mast cells

► We investigated the role of liprin-α, one of active zone proteins, in mast cell. ► Mast cells expressed liprin-α1, -α2 and -α3. ► Exocytotic release was impaired by knockdown of liprin-α1 in mast cells. ► Knockdown of liprin-α1 also inhibited cell spreading in mast cells.