کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117748 | 1591779 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibiotic treatment patterns across Europe in patients with complicated skin and soft-tissue infections due to meticillin-resistant Staphylococcus aureus: A plea for implementation of early switch and early discharge criteria
ترجمه فارسی عنوان
الگوهای درمان آنتی بیوتیک در سراسر اروپا در بیماران مبتلا به عفونت های پوستی و بافت نرم با توجه به استافیلوکوکوس اورئوس مقاوم به متیسیلین: درخواست برای پیاده سازی سوابق زود هنگام و مقررات ترخیص اولیه
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کلمات کلیدی
سوئیچ آنتی بیوتیکی داخل وریدی به دهان، مدت اقامت، روزهای خط وریدی، لینزولید، وانکومایسین، اقتصاد،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
This retrospective observational medical chart review aimed to describe country-specific variations across Europe in real-world meticillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft-tissue infection (cSSTI) treatment patterns, antibiotic stewardship activity, and potential opportunities for early switch (ES) from intravenous (i.v.) to oral formulations and early discharge (ED) from hospital using standardised data collection and criteria and economic implications of these opportunities. Patients were randomly sampled from 12 countries (Austria, Czech Republic, France, Germany, Greece, Ireland, Italy, Poland, Portugal, Slovakia, Spain and the UK), aged â¥18 years, with documented MRSA cSSTI, hospitalised between 1 July 2010 and 30 June 2011, discharged alive by 31 July 2011. Of 1502 patients, 1468 received MRSA-targeted therapy. Intravenous-to-oral switch rates ranged from 2.0% to 20.2%, i.v. length of therapy from 10.1 to 18.6 days and hospital length of stay (LoS) from 15.2 to 25.0 days across Europe. Of 341 sites, 82.9% had antibiotic steering committees, 23.7% had i.v.-to-oral switch antibiotic protocols and 12.9% had ED protocols for MRSA cSSTI. ES and ED eligibility ranged from 12.0% (Slovakia) to 56.3% (Greece) and from 10% (Slovakia) to 48.2% (Portugal), respectively. Potential cost savings per ED-eligible patient ranged from â¬414 (Slovakia) to â¬2703 (France). MRSA cSSTI treatment patterns varied widely across countries, but further reductions in i.v. therapy, hospital LoS and associated costs could be realised. These data provide insight into clinical practice patterns across diverse European healthcare systems and identify potential opportunities for local clinicians and policy-makers to improve clinical care and cost-effectiveness of this therapeutic area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 44, Issue 1, July 2014, Pages 56-64
Journal: International Journal of Antimicrobial Agents - Volume 44, Issue 1, July 2014, Pages 56-64
نویسندگان
Christian Eckmann, Wendy Lawson, Dilip Nathwani, Caitlyn T. Solem, Jennifer M. Stephens, Cynthia Macahilig, Damien Simoneau, Petr Hajek, Claudie Charbonneau, Richard Chambers, Jim Z. Li, Seema Haider,