کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6119113 | 1592279 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The properties of CD4+ regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-κB transcription factor RelA is constitutively active in naïve and effector Tregs. The conditional inactivation of Rela in murine FOXP3+ cells induces a rapid onset, multi-focal autoimmune disease that depends on RelA being expressed in conventional T cells. In addition to promoting Treg lineage stability, RelA determines the size of the effector Treg population, a function influenced by the presence or absence of RelA in conventional T cells. These findings showing that RelA controls Treg stability and promotes the competitive fitness of effector Tregs highlight the importance of RelA activity in peripheral Treg induced tolerance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 70, June 2016, Pages 52-62
Journal: Journal of Autoimmunity - Volume 70, June 2016, Pages 52-62
نویسندگان
Nicole Messina, Thomas Fulford, Lorraine O'Reilly, Wen Xian Loh, Jessica M. Motyer, Darcy Ellis, Catriona McLean, Haroon Naeem, Ann Lin, Raffi Gugasyan, Robyn M. Slattery, Raelene J. Grumont, Steve Gerondakis,