کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6119256 | 1592293 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nTH17 cell homeostasis in the thymus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nTH17 cell homeostasis in the thymus The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nTH17 cell homeostasis in the thymus](/preview/png/6119256.png)
چکیده انگلیسی
The interleukin-15 (IL-15) system is important for regulating both innate and adaptive immune responses, however, its role in autoimmune disease remained unclear. Here we found that Il15â/â and Il15raâ/â mice spontaneously developed late-onset autoimmune phenotypes. CD4+ T cells of the knockout mice showed elevated autoreactivity as demonstrated by the induction of lymphocyte infiltration in the lacrimal and salivary glands when transferred into nude mice. The antigen-presenting cells in the thymic medullary regions expressed IL-15 and IL-15Rα, whose deficiency resulted in insufficient negative selection and elevated number of natural IL-17A-producing CD4+ thymocytes. These findings reveal previously unknown functions of the IL-15 system in thymocyte development, and thus a new layer of regulation in T cell-mediated autoimmunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 56, January 2015, Pages 118-129
Journal: Journal of Autoimmunity - Volume 56, January 2015, Pages 118-129
نویسندگان
Mau-Sheng Hou, Shih-Ting Huang, Ming-Han Tsai, Ching-Cheng Yen, Yein-Gei Lai, Yae-Huei Liou, Chih-Kung Lin, Nan-Shih Liao,