کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6119288 | 1592299 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes](/preview/png/6119288.png)
چکیده انگلیسی
Previous cross-sectional analyses demonstrated that CD8+ and CD4+ T-cell reactivity to islet-specific antigens was more prevalent in T1D subjects than in healthy donors (HD). Here, we examined T1D-associated epitope-specific CD4+ T-cell cytokine production and autoreactive CD8+ T-cell frequency on a monthly basis for one year in 10 HD, 33 subjects with T1D, and 15 subjects with T2D. Autoreactive CD4+ T-cells from both T1D and T2D subjects produced more IFN-γ when stimulated than cells from HD. In contrast, higher frequencies of islet antigen-specific CD8+ T-cells were detected only in T1D. These observations support the hypothesis that general beta-cell stress drives autoreactive CD4+ T-cell activity while islet over-expression of MHC class I commonly seen in T1D mediates amplification of CD8+ T-cells and more rapid beta-cell loss. In conclusion, CD4+ T-cell autoreactivity appears to be present in both T1D and T2D while autoreactive CD8+ T-cells are unique to T1D. Thus, autoreactive CD8+ cells may serve as a more T1D-specific biomarker.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 50, May 2014, Pages 77-82
Journal: Journal of Autoimmunity - Volume 50, May 2014, Pages 77-82
نویسندگان
Ghanashyam Sarikonda, Jeremy Pettus, Sonal Phatak, Sowbarnika Sachithanantham, Jacqueline F. Miller, Johnna D. Wesley, Eithon Cadag, Ji Chae, Lakshmi Ganesan, Ronna Mallios, Steve Edelman, Bjoern Peters, Matthias von Herrath,