Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

► EndoS significantly reduced the anti-type VII collagen-mediated tissue destruction. ► EndoS also hydrolyzed already-tissue-bound pathogenic autoantibodies. ► EndoS differentially modulated the expression of Fcγ receptors in lesional skin. ► Modulation of autoantibody glycolysation is a potential therapeutic option in severe autoimmune diseases.