Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity

► IFN-γ is essential for idiopathic and chemical-induced systemic autoimmunity. ► Genetic redundancy of genes promoting IFN-γ expression produces little effect on chemically-induced systemic autoimmunity. ► Genes involved in the IFN-γ signaling pathway contribute significantly to all aspects of disease.