Epigenetics, autoimmunity and hematologic malignancies: A comprehensive review

► Immune dysregulation leads to autoimmune diseases and hematologic malignancies. ► Incidence of autoimmunity and lymphoma is high in primary immunodeficiencies. ► Epigenetic mechanisms play a major role in dysregulation of Th17/Treg homeostasis. ► Tregs and Th17 imbalance contributes to autoimmunity and hematologic malignancies.