کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6120600 | 1592365 | 2014 | 6 صفحه PDF | دانلود رایگان |
- Systematic antimicrobials are recommended in community-acquired pneumonia of child.
- A large panel of bacteria and viruses was detected in 85 children exhibiting CAP.
- More than 60% of children with CAP exhibited an exclusive viral infection.
- A co-infection with at least 2 viruses was observed in >40% of the children.
- Data suggest that the use of antimicrobials in child's CAP should be revisited.
BackgroundThe management of children with community-acquired pneumonia (CAP) is largely influenced by the development of new molecular diagnostic tests that allow the simultaneous detection of a wide range of pathogens.ObjectivesEvaluation of a diagnostic approach including multiplex PCR assays for revisiting the epidemiology and etiology of CAP in children at hospital.Study designChildren of all ages consulting at the Emergency Department of the University hospital of Saint-Etienne, France, during the 2012-2013 winter period were included. In addition to bacterial cultures, the following pathogens were detected using biplex commercially-available rt-PCR tests: adenovirus, respiratory syncytial virus, human metapneumovirus, bocavirus, rhinovirus/enterovirus, coronavirus, influenza viruses A and B, parainfluenza viruses, Mycoplasma pneumoniae and Chlamydophila pneumonia.ResultsFrom 85 patients with CAP, at least one pathogen was identified in 81 cases (95.3%), including 4 bacterial exclusive infections (4.7%), 53 viral exclusive infections (62.4%) and 24 mixed infections (28.2%). Coinfection by at least two viruses was observed in 37 cases (43.5%). Mean age was higher in the case of documented bacterial infection (PÂ <Â 0.05). In the subgroup of viral exclusive infection, the mean age of severe cases was 2.0 years vs 3.8 years in mild and moderate cases (PÂ <Â 0.05).ConclusionsThese findings highlight the huge proportion of CAP of viral origin, the high number of co-infection by multiple viruses and the low number of bacterial CAP, notably in children under 5 years, and address the need to re-evaluate the indications of empiric antimicrobial treatment in this age group.
Journal: Journal of Clinical Virology - Volume 60, Issue 4, August 2014, Pages 402-407